Alkaline conditions accelerate polymorphonuclear leukocyte apoptosis in vitro.
نویسندگان
چکیده
Apoptosis was monitored in polymorphonuclear leukocytes (PMNs) cultured under mildly acidic, neutral, and alkaline conditions. Within 3 h, 9.0% of the PMNs underwent apoptosis at pH 6.7, as did 12% at pH 7.2, 38% at pH 7.7, and 60% at pH 8.2. Inhibitors of serine proteases, caspase-1, or caspase-3 significantly inhibited PMN apoptosis at pH 8.2, suggesting an involvement by these enzymes.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 67 4 شماره
صفحات -
تاریخ انتشار 1999